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 Brand name: rosiglitazone
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Dose-related weight gain was seen with rosiglitazone alone and in combination with other hypoglycemic agents. Overall, the types of adverse reactions without regard to causality reported when rosiglitazone was used in combination with metformin were similar to those reported during monotherapy with rosiglitazone. White blood cell counts also decreased slightly in adult patients treated with rosiglitazone. Compared to patients receiving placebo, patients with congestive heart failure (CHF) receiving rosiglitazone also experienced more cardiovascular deaths, more CHF worsening, more new or worsening dyspnea, more increases in CHF medication and cardiovascular hospitalization, more myocardial infarctions, and angina. 1%) were greater in patients treated with rosiglitazone added to metformin compared to monotherapy with rosiglitazone. The time course and magnitude of decreases were similar in patients treated with a combination of rosiglitazone and other hypoglycemic agents or monotherapy with rosiglitazone.

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